abstract：OBJECTIVE:To determine the possible interaction between the antihypertensive agent cicletanine and the hypoglycaemic drug tolbutamide. METHODS:Time-courses of glycaemia and serum immunoreactive insulin (IRI) were followed in 10 healthy subjects after two tolbutamide infusions in each volunteer; initially alone and 9 d...

journal_title：European journal of clinical pharmacology

authors： Bayés MC,Barbanoj MJ,Vallès J,Torrent J,Obach R,Jané F

更新日期：1996-01-01 00:00:00

abstract：:The systemic effects of single and multiple doses of inhaled fluticasone propionate (FP) and budesonide were examined in 24 healthy male volunteers (age range 18-29 years). The study was of an open, placebo-controlled, randomized, three-way crossover design. On each study day, multiple blood samples were taken over a ...

journal_title：European journal of clinical pharmacology

authors： Lönnebo A,Grahnén A,Jansson B,Brundin RM,Ling-Andersson A,Eckernäs SA

更新日期：1996-01-01 00:00:00

abstract：OBJECTIVE:We recently reported a highly stereoselective increase in plasma concentrations of (S)-atenolol during exercise which is most likely due to a release of the drug from adrenergic cells. The objective of the present study was to investigate the influence of physical exercise on plasma concentrations of the (R)-...

journal_title：European journal of clinical pharmacology

authors： Stoschitzky K,Schumacher M,Stark G,Dimai HP,Stauber R,Stoschitzky P,Krejs GJ,Klein W,Lindner W

更新日期：1996-01-01 00:00:00

abstract：OBJECTIVE:In order to document the stereoselective distribution in joints of a chiral nonsteroidal anti-inflammatory drug, the relative affinities of the enantiomers of tiaprofenic acid in synovium and for cartilage were compared. METHODS:The distribution of tiaprofenic acid in synovium and in cartilage was studied 25...

journal_title：European journal of clinical pharmacology

authors： Lapicque F,Mainard D,Gillet P,Payan E,Bannwarth B,Netter P

更新日期：1996-01-01 00:00:00

abstract：:Our goal was to develop a pharmacokinetic-pharmacodynamic model that describes the fate of atracurium and its metabolite laudanosine as well as the time course of the neuromuscular block. The model was based on the consideration of mass balance of atracurium and was constructed by postulating an effect compartment lin...

journal_title：European journal of clinical pharmacology

authors： Nigrovic V,Gaspari J,Banoub M

更新日期：1996-01-01 00:00:00

abstract：OBJECTIVES:An increased risk of all-cause and cardiovascular mortality in users of anxiolytic-hypnotic drugs (AHD) has been reported, and use of analgesics may be an additional factor. Therefore, we examined the association of AHD and analgesic use, alone and in combination, with all-cause and ischaemic heart disease (...

journal_title：European journal of clinical pharmacology

authors： Merlo J,Hedblad B,Ogren M,Ranstam J,Ostergren PO,Ekedahl A,Hanson BS,Isacsson SO,Liedholm H,Melander A

更新日期：1996-01-01 00:00:00

abstract：OBJECTIVE:In a double blind, randomised, placebo-controlled, cross-over study 12 healthy male volunteers were allocated to receive felodipine + placebo, cyclosporine + placebo, and felodipine + cyclosporine in order to investigate the interaction between the calcium channel blocker felodipine and cyclosporine as it aff...

journal_title：European journal of clinical pharmacology

authors： Madsen JK,Jensen JD,Jensen LW,Pedersen EB

更新日期：1996-01-01 00:00:00

abstract：:A series of elegant experimental studies and careful clinical observation over a decade or more have led to the concept of 'infarct expansion' and 'remodelling' of the heart, culminating in a number of major mortality studies indicating the effectiveness of angiotensin-converting enzyme (ACE) inhibitors in patients af...

journal_title：European journal of clinical pharmacology

authors： Reynolds G,Hall AS,Ball SG

更新日期：1996-01-01 00:00:00

abstract：OBJECTIVE:Nafamostat mesilate, a potent protease inhibitor, is widely used for the treatment of pancreatitis, disseminated intravascular coagulation and as an anticoagulant in haemodialysis. However, hyperkalaemia associated with nafamostat mesilate has been reported. It is thought to be due to decreased urinary potass...

journal_title：European journal of clinical pharmacology

authors： Ookawara S,Tabei K,Sakurai T,Sakairi Y,Furuya H,Asano Y

更新日期：1996-01-01 00:00:00

abstract：OBJECTIVE:Case report of a pharmacokinetic interaction between diltiazem and nortriptyline. METHODS:Determination of plasma nortriptyline concentrations by HPLC. Calculation of nortriptyline clearances and half-life by formulae used routinely in therapeutic drug monitoring. RESULTS:The average plasma concentration of...

journal_title：European journal of clinical pharmacology

authors： Krähenbühl S,Smith-Gamble V,Hoppel CL

更新日期：1996-01-01 00:00:00

abstract：:A new technique which combines skin microinjection of minute amounts of drugs (0.5 microliter) and measurement of capillary permeability by intravital fluorescence videomicroscopy and densitometry is introduced. Glass micropipettes with a tip diameter of 7-9 microns are inserted by a micromanipulator into the stratum ...

journal_title：European journal of clinical pharmacology

authors： Herrig I,Hoffmann U,Fischer M,Franzeck UK,Bollinger A

更新日期：1996-01-01 00:00:00

abstract：:The function of the hepatic P450 enzyme system was evaluated by measuring the kinetics of antipyrine and serum sex hormone levels were determined in 12 male patients with epilepsy during carbamazepine medication, and two and six months after changing their medication to oxcarbazepine. Antipyrine t1/2 increased and ant...

journal_title：European journal of clinical pharmacology

authors： Isojärvi JI,Pakarinen AJ,Rautio A,Pelkonen O,Myllylä VV

更新日期：1995-01-01 00:00:00

abstract：:The influence of isosorbide dinitrate (ISDN) and food ingestion on superior mesenteric artery impedance was investigated in 24 healthy volunteers (age 40 +/- 2.7 years). Superior mesenteric artery circulation was assessed by duplex ultrasound. Pulsatility index (PI) was considered as a parameter of vascular resistance...

journal_title：European journal of clinical pharmacology

authors： Voet D,Mareels S,Afschrift M,De Buyzere M,Rietzschel E,Duprez D

更新日期：1995-01-01 00:00:00

abstract：:The aim of this multicentre randomised double blind study was to compare the efficacy and safety of the 200-300 mg sustained release diltiazem formulation administered once daily (200-300 SR) with standard diltiazem (D) given three or four times daily to patients with stable angina. Patients aged 59 years, with a repr...

journal_title：European journal of clinical pharmacology

authors： Trimarco B,Radzik D,Van Mieghem W,Neveux E,Wajman A,Attali P,Ponsonnaille J

更新日期：1995-01-01 00:00:00

abstract：UNLABELLED:The steady-state pharmacokinetics of nefazodone (NEF) and its metabolites hydroxynefazodone (HO-NEF) and m-chlorophenylpiperazine (mCPP) were compared in subjects with normal and impaired renal function. PATIENTS:The Study was of parallel group design which included 7 subjects with normal (NOR) renal functi...

journal_title：European journal of clinical pharmacology

authors： Barbhaiya RH,Brady ME,Shukla UA,Greene DS

更新日期：1995-01-01 00:00:00

abstract：:Quinidine is a very potent inhibitor of CYP2D6, but the role of the enzyme in the biotransformation of quinidine has only been investigated in a single in vitro study and in two small in vivo experiments, with contradictory results. The present investigation was designed to present definite evaluation of whether quini...

journal_title：European journal of clinical pharmacology

authors： Nielsen F,Rosholm JU,Brøsen K

更新日期：1995-01-01 00:00:00

abstract：:The aim of the study was to examine the effect of chronic angiotensin converting enzyme inhibition on haemodynamics and left ventricular performance during long-lasting exercise at the anaerobic threshold. For this purpose exercise haemodynamics and left ventricular performance were assessed in 14 physically trained h...

journal_title：European journal of clinical pharmacology

authors： Palatini P,Bongiovi S,Mario L,Mormino P,Raule G,Pessina AC

更新日期：1995-01-01 00:00:00

abstract：:Changes in phenytoin concentrations caused by switching valproate formulations with different absorption rates were retrospectively investigated in eleven epileptic patients receiving treatment with both drugs. Total plasma phenytoin concentrations were measured before and after a standard tablet of valproate was repl...

journal_title：European journal of clinical pharmacology

authors： Suzuki Y,Nagai T,Mano T,Arai H,Kodaka R,Matsuoka T,Itagaki Y,Ono J,Okada S

更新日期：1995-01-01 00:00:00

abstract：:The incidence of vasodilation-related events (flushing, headache, dizziness and oedema) was determined in a total of 37,670 patients treated with diltiazem, nicardipine, isradipine or amlodipine and studied by Prescription-Event Monitoring between 1984 and 1991. Event rates are expressed as the percentage of patients ...

journal_title：European journal of clinical pharmacology

authors： Kubota K,Pearce GL,Inman WH

更新日期：1995-01-01 00:00:00

abstract：:A randomised, placebo controlled clinical trial was conducted to examine the efficacy of a homeopathic after-bite gel in the symptomatic relief of mosquito bites. Sixty eight healthy volunteers were bitten under laboratory conditions by Aedes aegypti mosquitoes at three spots, on the ventral aspect of the forearm. One...

journal_title：European journal of clinical pharmacology

authors： Hill N,Stam C,Tuinder S,van Haselen RA

更新日期：1995-01-01 00:00:00

abstract：:The effects of an oral dose of atropine (0.03 mg/kg body weight) and an IM (0.02 mg/kg) dose on the heart rate and salivary flow in seven healthy adult volunteers were compared to see whether the oral dose was sufficient to inhibit vagal reflexes of the heart. Atropine concentrations in plasma were determined by an M2...

journal_title：European journal of clinical pharmacology

authors： Volz-Zang C,Waldhäuser T,Schulte B,Palm D

更新日期：1995-01-01 00:00:00

abstract：:Idrapril is the prototype of a new class of ACE inhibitors, characterised by the presence of a hydroxdmic group. Six untreated in-patients with essential hypertension were given single oral doses of the calcium salt of idrapril, idrapril calcium (200 mg) and placebo according to a double blind, randomised experimental...

journal_title：European journal of clinical pharmacology

authors： Taddei S,Ghiadoni L,Mattei P,Sudano I,Duranti P,Favilla S,Virdis A,Romagnoli A,Criscuoli M,Coppini A

更新日期：1995-01-01 00:00:00

abstract：:Red cell folate concentrations were determined in 74 epileptic women in early pregnancy in a prospective study. All patients were treated continuously with antiepileptic drugs since before conception. The most frequently used drugs were carbamazepine (n = 39) and phenytoin (n = 26). Sixty-four patients (86%) were on m...

journal_title：European journal of clinical pharmacology

authors： Tomson T,Lindbom U,Sundqvist A,Berg A

更新日期：1995-01-01 00:00:00

abstract：:The pharmacokinetics of lorazepam was examined in 10 male patients with insulin-dependent diabetes mellitus before and following treatment with neomycin and cholestyramine. Neomycin and cholestyramine were given in an attempt to block the enterohepatic circulation of lorazepam and so to permit an in vivo estimate of h...

journal_title：European journal of clinical pharmacology

authors： Herman RJ,Chaudhary A,Szakacs CB,Woo D,Lane R,Boctor MA

更新日期：1995-01-01 00:00:00

abstract：:To elucidate the effect of Nicorandil on myocardial energy metabolism and myocardial sympathetic activity, we administered Nicorandil orally to eight patients with angina pectoris prior to exercise testing. Arterial and coronary sinus levels of lactate, ammonia, hypoxanthine (HX), adrenaline and noradrenaline were mea...

journal_title：European journal of clinical pharmacology

authors： Ogino K,Osaki S,Noguchi N,Kitamura H,Omodani H,Kato M,Hisatome I,Matsumoto T,Kinugawa T,Miyakoda H

更新日期：1995-01-01 00:00:00

abstract：:This study assessed the influence of acetylsalicylic acid (ASA, 1.0 g), ibuprofen (0.8 g) and paracetamol (1.0 g) on the single-dose kinetics of ethanol in 12 healthy volunteers ingesting the drug and a standardised 1840-kJ breakfast 1 h before intake of ethanol. It also assessed the influence of ethanol on the single...

journal_title：European journal of clinical pharmacology

authors： Melander O,Lidén A,Melander A

更新日期：1995-01-01 00:00:00

abstract：:Naftopidil exerts its antihypertensive action via alpha 1-adrenoceptor blockage and Ca2+ antagonism in vascular smooth muscle. Since the chemically similar 1-(1-naphthyl) piperazine is known to be a 5-hydroxytryptamine2 receptor antagonist, the 5-hydroxytryptamine (5-HT) antagonistic properties of naftopidil were test...

journal_title：European journal of clinical pharmacology

authors： Kirsten R,Breidert M,Nelson K,Heine A,Rosenkranz S,Erdeg B,Niebch G,Borbe HO,Siebert-Weigel M,Respondek J

更新日期：1994-01-01 00:00:00

abstract：:The cardiovascular and central nervous system effects of the kappa opioid receptor agonist U-62066E were investigated in ten normal male subjects who received U-62066E or placebo with low or high dose naloxone in a randomized, double blind study. Blood pressure and heart rate in the supine and standing position, plasm...

journal_title：European journal of clinical pharmacology

authors： Rimoy GH,Wright DM,Bhaskar NK,Rubin PC

更新日期：1994-01-01 00:00:00

abstract：:Ten normal adult tobacco smokers and 10 nonsmoking volunteers 20-31 years of age were the subjects of this study. The tobacco smokers all had a history of daily tobacco smoking. They were asked to stop smoking for 12 hours prior to testing. The Hoffmann (H) reflex and its recovery cycle were measured on different days...

journal_title：European journal of clinical pharmacology

authors： Domino EF,Kadoya C,Matsuoka S

更新日期：1994-01-01 00:00:00

abstract：:The Danish retail pharmacies' drug subsidy system is completely computerized. The data are person-identifiable, making it possible to chart the population's drug use from the perspective of individual users. We decided to explore the potential of this data source and to analyse heavy drug users specifically. The analy...

journal_title：European journal of clinical pharmacology

authors： Hallas J,Nissen A

更新日期：1994-01-01 00:00:00

abstract：:The frequency distribution of the 8-h urinary ratio of log metoprolol/alpha-hydroxymetoprolol was assessed in 65 healthy, unrelated Jordanian volunteers. There was no apparent bimodality in the frequency distribution of this ratio among the subjects studied. The frequency of the poor metabolizer phenotype of metoprolo...

journal_title：European journal of clinical pharmacology

authors： al-Hadidi HF,Irshaid YM,Rawashdeh NM

更新日期：1994-01-01 00:00:00

abstract：:A new device for IV admixtures has been developed in Israel, the Vialink minibag. It consists of a partly filled minibag, attached by rubber tubing to a sterile receptable into which various types of vials containing drugs can be firmly inserted. Time and motion studies were conducted to determine the time and cost as...

journal_title：European journal of clinical pharmacology

authors： Lustig A

更新日期：1994-01-01 00:00:00

abstract：:The inhibitory action of azelastine hydrochloride (Azeptin) on the respiratory burst in peripheral polymorphonuclear leukocytes (PMN) and pulmonary alveolar macrophages (PAM) has been studied. Azeptin in vitro suppressed chemiluminescence and superoxide (O2-) generation by human PMN in a dose- and time-dependent manne...

journal_title：European journal of clinical pharmacology

authors： Ueta E,Osaki T,Kawasaki N,Nomura Y

更新日期：1994-01-01 00:00:00

abstract：:The bioavailability of four preparations containing dihydrotachysterol (DHT2) was tested in two separate trials with administration of single, oral doses of 1 mg per individual. The relative bioavailability of corresponding preparations (capsules vs capsules and oral solution vs oral solution) was tested in a randomis...

journal_title：European journal of clinical pharmacology

authors： Koytchev R,Alken RG,Vagaday M,Kunter U,Kirkov V

更新日期：1994-01-01 00:00:00

abstract：:We have found transient circulating neutropenia and pulmonary sequestration of neutrophils after the intravenous injection of vindesine, a microtubule disruptor. Experiment 1 Ten patients with lung cancer were given a bolus intravenous injection of 3 mg.m-2 vindesine (Fildesine(r)). In all patients, total leukocyte an...

journal_title：European journal of clinical pharmacology

authors： Aoshiba K,Nagai A,Ueno H,Konno K

更新日期：1994-01-01 00:00:00

abstract：:Serotonin (5-HT) stimulates prolactin release. In the present study the ability of dexfenfluramine to increase serum prolactin was used as an index of central 5-HT function after acute and chronic pretreatment of volunteers with fluoxetine. Following a single-blind, random design, on each experimental day each volunte...

journal_title：European journal of clinical pharmacology

authors： Sommers DK,van Wyk M,Snyman JR

更新日期：1994-01-01 00:00:00

abstract：:An expert meeting to discuss population pharmacokinetic/pharmacodynamic software was held in Brussels in November 1993 under the auspices of the European Co-operation in Science and Technology (COST), Medicine (B1) programme. Recently developed statistical methods offer the possibility of gaining integrated informatio...

journal_title：European journal of clinical pharmacology

authors： Aarons L,Balant LP,Mentré F,Morselli PL,Rowland M,Steimer JL,Vozeh S

更新日期：1994-01-01 00:00:00

abstract：:Dexmedetomidine is a novel alpha 2-adrenoceptor agonist that may provide beneficial effects as premedication for anesthesia. The pharmacokinetics and pharmacodynamics of transdermal (TD) and intravenous (i.v.) dexmedetomidine were studied in nine healthy male subjects in a crossover trial. The TD preparation, containi...

journal_title：European journal of clinical pharmacology

authors： Kivistö KT,Kallio A,Neuvonen PJ

更新日期：1994-01-01 00:00:00

abstract：:All forensic autopsy cases in southern Sweden in 1986-89 in which antidepressant drugs were found in the blood were assessed and the findings related to the sales of antidepressants as expressed as defined daily doses per 1,000 inhabitants per day. There was a total of 272 antidepressant-positive cases, which were div...

journal_title：European journal of clinical pharmacology

authors： Malmvik J,Löwenhielm CG,Melander A

更新日期：1994-01-01 00:00:00

abstract：:The study was done in healthy volunteers to investigate the vasoconstrictor activity of three commercially available formulations of fluocinolone acetonide (Synalar gel, cream and ointment) and to determine whether they were bioequivalent. The influence of dilution of the cream formulation on activity was also examine...

journal_title：European journal of clinical pharmacology

authors： Gao HY,Li Wan Po A

更新日期：1994-01-01 00:00:00